Fig 1: Changes in the oxidant/antioxidant markers in the lung of saline-instilled animals (Control), silica-instilled non-treated animals (Model), and EGCG-treated silica-instilled animals (EGCG) after 14 days (14d) or 28 days (28d) of the treatment delivery. Abbreviations: TAC: total antioxidant capacity; SOD: superoxide dismutase; Nrf2: nuclear factor erythroid-derived 2-like factor 2; HO-1: heme oxygenase; NQO-1: NAD(P)H:quinone oxidoreductase-1; NLRP3: nucleotide-binding and oligomerization domain-like receptor. For statistical differences among the groups: * p < 0.05 for Model14d vs. Control14d; + p < 0.05 and ++ p < 0.01 for EGCG14d vs. Model14d; # p < 0.05 for Model28d vs. Control28d; & p < 0.05 and && p < 0.01 for EGCG28d vs. Model28d.
Fig 2: Effect of dapagliflozin and/or hesperidin on (A) TGF-β1, (B) NF-κB, (C) MCP-1, and (D) NLRP3 inflammasome in the hippocampal tissues of rats injected with lipopolysaccharide (Mean ± SD). a p-value < 0.05 versus the control group; b p-value < 0.05 versus LPS-injected group; c p-value < 0.05 versus LPS rats treated with dapagliflozin; d p-value < 0.05 versus LPS rats treated with hesperidin. LPS (lipopolysaccharide), DMSO (dimethyl sulfoxide), DPF (dapagliflozin), and HSP (hesperidin).
Supplier Page from Wuhan Fine Biotech Co., Ltd. for Rat NLRP3(Nod Like Receptor Pyrins-3) ELISA Kit